Targeting tumor cells with antibodies enhances anti-tumor immunity
نویسندگان
چکیده
منابع مشابه
Tumor-binding antibodies and tumor immunity
The remarkable capacity of the immune system to distinguish self from non-self makes it almost impossible to transmit cancers (or organs) from one individual to another in the absence of immunosuppressive drugs. Whereas rejection of donor cells bearing mismatched MHC alleles has been ascribed to direct activation of T cells by the altered MHC-peptide structures, the factors that initiate reject...
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The use of innate immune receptor agonists in cancer therapies has suffered from many drawbacks. Our recent observations suggest that some of these hurdles can be overcome by introducing flagellin into tumor cells to promote tumor antigen presentation by dendritic cells (DCs) and simultaneously trigger two types of pattern recognition receptors (PRRs).
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MiRNA (miR)-128, which is a well‑recognized inhibitor of tumor growth, is involved in the anti-tumor function of dendritic cells (DCs). However, the association between miR‑128 and the DC‑mediated anti‑tumor immunity remains to be elucidated. Murine B16 melanoma cells and C57BL/6 male mice were used to obtain marrow‑derived DCs. DCs were treated with B16 cell suspension. miR‑128 mimic, miR‑128 ...
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Carcinoembryonic antigen (CEA, CEACAM5, and CD66e) has been found to be associated with various types of cancers, particularly colorectal carcinoma, and developed to be a molecular target for cancer diagnosis and therapy. In present study, we generated a novel anti-CEACAM5 monoclonal antibody, namely mAb CC4, by immunizing mice with living colorectal cancer LS174T cells. Immunohistochemical stu...
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PURPOSE Angiogenesis is a key process in tumor progression. By binding VEGF, VEGF receptor-2 (VEGFR2) is a main signaling transducer in tumor-associated angiogenesis. Accordingly, therapeutic approaches against the VEGF/VEGFR2 signaling axis have been designed. However, an efficient and specific chemotherapeutic targeting of tumor-associated endothelial cells has not yet been achieved. EXPERI...
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ژورنال
عنوان ژورنال: Biophysics Reports
سال: 2018
ISSN: 2364-3439,2364-3420
DOI: 10.1007/s41048-018-0070-2